Hashimoto thyroiditis is associated with which antibodies?

Hashimoto thyroiditis is associated with which antibodies?

• A. Anti-TSH receptor
• B. ANA
• C. Anti-dsDNA
• D. Antimicrosomal, antithyroglobulin, antithyroid peroxidase

Answer: (D)

Hashimoto thyroiditis is an autoimmune attack on the thyroid where the immune system targets thyroid components. The most characteristic antibodies are against thyroid peroxidase (TPO) and thyroglobulin. Antimicrosomal antibodies are an older name for anti-TPO antibodies, and antithyroglobulin antibodies may also be present. These antibody responses contribute to gradual thyroid destruction and often hypothyroidism. Antibodies to the TSH receptor are more typical of Graves disease and cause stimulation of the thyroid, not Hashimoto. General autoimmune markers like ANA or anti-dsDNA relate to other diseases and are not specific to Hashimoto.

Hashimoto thyroiditis is an autoimmune attack on the thyroid where the immune system targets thyroid components. The most characteristic antibodies are against thyroid peroxidase (TPO) and thyroglobulin. Antimicrosomal antibodies are an older name for anti-TPO antibodies, and antithyroglobulin antibodies may also be present. These antibody responses contribute to gradual thyroid destruction and often hypothyroidism. Antibodies to the TSH receptor are more typical of Graves disease and cause stimulation of the thyroid, not Hashimoto. General autoimmune markers like ANA or anti-dsDNA relate to other diseases and are not specific to Hashimoto.