Mutations in which gene are associated with MEN 1?

Mutations in which gene are associated with MEN 1?

• A. BRCA1
• B. RET
• C. APC
• D. MEN1 (menin)

Answer: (D)

Mutations in the MEN1 gene are associated with MEN 1. The MEN1 gene encodes menin, a tumor suppressor protein. When MEN1 is inactivated, individuals develop tumors in tissues classically affected by MEN1—parathyroid, pituitary, and pancreatic islet cells. Among the listed genes, BRCA1 is linked to breast/ovarian cancer risk; RET mutations cause MEN2 with medullary thyroid carcinoma; APC mutations cause familial adenomatous polyposis. So the gene tied to MEN 1 is MEN1, encoding menin.

Mutations in the MEN1 gene are associated with MEN 1. The MEN1 gene encodes menin, a tumor suppressor protein. When MEN1 is inactivated, individuals develop tumors in tissues classically affected by MEN1—parathyroid, pituitary, and pancreatic islet cells. Among the listed genes, BRCA1 is linked to breast/ovarian cancer risk; RET mutations cause MEN2 with medullary thyroid carcinoma; APC mutations cause familial adenomatous polyposis. So the gene tied to MEN 1 is MEN1, encoding menin.